The development and use of iridium(l) phosphine systems for ortho-directed hydrogen-isotope exchange

摘要

Rapid and efficient iridium-mediated hydrogen-tritium exchange labeling of pharmaceutical compounds is a key methodology in the life sciences industry. A review of the development and use of iridium(l) phosphine systems for ortho-directed isotopic exchange is described to provide the reader with a comprehensive introduction to the area and to serve as a starting point for experimental investigators. Examples of useful catalyst systems and their application to different substrates types as well as potential areas for further development are discussed.