Radiosynthesis of a 123I-labeled clorgiline derivative for MAO-A imaging

摘要

It has been shown that, the regional distributions of MAO-A and B can be identified in human brain in vivo with intravenously injected labelled clorgyline and L-deprenyl, respectively. These labelled compounds can be used in imaging of MAO-B in peripheral organs in humans, turnover MAO-B, measurement of human cerebral MAO-B activity, reduced lung MAO in smokers and its different binding in human brain. Structure activity relationship of MAO inhibitors has shown that the presence of two halide atoms at positions 2 and 4, enhances the inhibition, the idea was to replace the chlorine at the position 2 with an iodine-123 atom to retain the inhibition effect as well as create a labeled compound.