Synthesis of [15N]t-butylamine hydrochloride

摘要

This report presents an efficient synthesis of [15N]t-butylamine hydrochloride. Acylation of [15N]ammonia with pivaloyl chloride provided [15N]pivalamide, this was converted to benzyl [ 15N]N-t-butylcarbamate through a Hofmann rearrangement. Hydrogenolysis of benzyl [15N]N-t-butylcarbamate and acidification afforded [15N]t-butylamine hydrochloride in an overall yield of 79.2% in four steps.