Development of an immunoradiometric assay (IRMA) kit for determination of thyroid stimulating hormone in dry blood spot of newborns

摘要

Congenital hypothyroidism will lead to mental retardation if untreated. Treatment must begin very early, because half of the human postnatal brain growth is completed by six month of age. The measurement of thyroid stimulating hormone (TSH) by immunometric assay is the most sensitive test for early detection of congenital hypothyroidism.