Isotope effect on chemical shifts in hydrogen-bonded systems

摘要

An overview of recent developments in the use of isotope effects in hydrogen-bonded systems with special emphasis on intramolecular hydrogen bonding is given. The systems investigated cover both resonance-assisted hydrogen bonded (RAHB) and non-RAHB systems. Deuterium isotope effects on 13C chemical shifts are discussed extensively together with effects on 1H, 19F and 15N chemical shifts. The compounds cover a large range from hydrogen-bonded esters over amides, thioamides, Schiff bases also covering proteins, nucleic acids and carbohydrates. Isotope effects are discussed both in static and tautomeric systems and in the liquid and solid states. Theoretical approaches to isotope effects on chemical shifts are likewise treated.