Production and biological evaluation of (201TI(lll))bleomycin

摘要

The development of 201Tl(III)radiopharmaceutlcals could provide many advantages: (a) the physical properties of T1 are interesting; (b) the chemistry of 2O1T1(III) complexation molecule is simple; (c) the complexation constant for most of Tl(III) complexes are among the highest (for instance, T1(III)-DTPA at 25degC, logK = 46) for all metal-chelator complexes; (d) high specific activity radiopharmaceuticals can be synthesized in kit formulations; (e) 201Tl is available in many parts of the developed and developing world and can offer alternatives for other metallic radioisotopes including.