Carbimazole induced eosinophilic granulomatous vasculitis localized to the stomach.

摘要

Abstract. Seve P, Stankovic K, Michalet V, Vial T, Scoazec J-Y, Broussolle C (Hotel Dieu, 1 place de l'Hopital, Lyon Cedex 02; Hopital de la Croix-Rousse, Lyon Cedex 04; Regional Pharmacoviligance Center, Lyon Cedex 03; and Hopital Edouard-Herriot, Lyon Cedex 03; France). Carbimazole induced eosinophilic granulomatous vasculitis localized to the stomach (Case report). J Intern Med 2005; 258: 191-195.Vasculitis associated with anti-neutrophil cytoplasmic antibodies has been reported in patients treated with anti-thyroid drugs and especially propylthiouracil. We report here a case of granulomatous eosinophilic vasculitis mimicking gastric neoplasm and peripheral eosinophilia in a 27-year-old man who was treated with carbimazole for 5 months for Graves' disease. Clinical and morphologic features resolved within 2 months after stopping the drug, suggesting a causative role for the drug. To our knowledge, this is the first biopsy-proven granulomatous eosinophilic vasculitis associated with this drug.