Evaluation of In Vivo Properties of Velosorb (TM) Fast Versus Vicryl (TM) Rapide in a Functional Rabbit Model of Intradermic Suture and Episiotomy

摘要

Objective: Fast-absorbing polyglactin 910 is commonly used to suture skin and vaginal incisions. In vitro studies have shown similar tensile strength properties between Velosorb (TM) Fast and Vicryl (TM) Rapide (Al-Qattan MM. J Hand Surg Br Eur. 2005;30(1):90-91). This randomized study compared Velosorb (TM) Fast (Covidien) with Vicryl (TM) Rapide (Ethicon) in a rabbit model of intradermic suture and episiotomy. Materials and Methods: This randomized prospective study was performed on 20 New Zealand rabbits, in which we realized a mediolateral perineovaginal incision and two vertical skin incisions of about 8 cm on the abdominal wall. The sutures were randomized between Velosorb (TM) Fast (Covidien) and Vicryl (TM) Rapide (Ethicon), and each rabbit was treated with the same suture on both vaginal incision and left abdominal incision, while the right abdominal incision was closed with an alternate suture. A macroscopic examination was performed on days 5 and 11. On day 11, animals were sacrificed for histological (Badylak quantitative score) and electron microscopic examinations. Differences were considered significant at p < .05. Results: All of the rabbits survived and were included in the final results. Fifty-one sutures were visible by histologic analysis (27 in the Velosorb (TM) Fast group and 24 in the Vicryl (TM) Rapide group). The power of the study was >= 80%. There was no significant difference between the two groups based on the total histologic Badylak score analysis or the Badylak sub-score analysis. Conclusions: Velosorb (TM) Fast seems to be as efficient as Vicryl (TM) Rapide for use in perineal and skin closure.