NON-LINEAR SPECTRAL IMAGING MICROSCOPY STUDIES OF HUMAN HYPERTROPHIC SCAR

摘要

Skin scar is unique to humans, the major significant negative outcome sustained after thermalinjuries, traumatic injuries, and surgical procedures. Hypertrophic scar in human skin is investi-gated using non-linear spectral imaging microscopy. The high contrast images and spectroscopicintensities of collagen and elastic fibers extracted from the spectral imaging of normal skin tis-sue, and the normal skin near and far away from the hypertrophic scar tissues in a 10-year-oldpatient case are obtained. The results show that there are apparent differences in the morpho-logical structure and spectral characteristics of collagen and elastic fibers when comparing thenormal skin with the hypertrophic scar tissue. These differences can be good indicators to differ-entiate the normal skin and hypertrophic scar tissue and demonstrate that non-linear spectralimaging microscopy has potential to noninvasively investigate the pathophysiology of humanhypertrophic scar.