A new mononuclear manganese(III) complex of an unsymmetrical hexadentate N3O3 ligand exhibiting superoxide dismutase and catalase-like activity: synthesis, characterization, properties and kinetics studies

摘要

A mononuclear Mn-III complex MnL center dot 4H(2)O (H3L = 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N'-(2-hydroxybenzyl),N'-(4-methylbenzyl)amino]propan-2-ol) has been prepared and characterized. This complex catalyzes the dismutation of superoxide efficiently, with catalytic rate constant k(cat) = 1.7 x 10(6) M-1 s(-1) and IC50 1.26 mu M, obtained through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. MnL is also able to disproportionate more than 300 equivalents of H2O2 in CH3CN, with initial rate of H2O2 decomposition given by r(i) = k(cat) [MnL](2) [H2O2] and k(cat) = 1.32(2) mM(-2) min(-1). The accessibility of the Mn-IV state (E-P = 0.53 V vs. saturated calomel electrode), suggests MnL employs a high-valent catalytic cycle to decompose O-2 center dot(-) and H2O2. (C) 2015 Elsevier Inc. All rights reserved.