Synthesis, structures and in vitro cytotoxicity of some cationic cis-platinum(II) complexes containing chelating thiocarbamates

摘要

The thiocarbamates 4-RC6H4NHC(S)NR2′ (R = H, Cl; R′ = Me, Et), 4-ClC6H4NHC(S)NR (NR = 2-pyridylpiperazine) react with cis-[PtCl2(PTA)2] (PTA = 1,3,5-triaza-7-phosphaadamantane) in the presence of base to afford the monocationic platinum(II) complexes cis-[Pt{SC(NR2′) = NC 6H4R}(PTA)2]+ (R = H, Cl; R′ = Me, Et), cis-[Pt{SC(NR) = NC6H4Cl}(PTA)2] + (NR = 2-pyridylpiperazine), which were isolated as their PF 6 salts in high yields. The complexes were fully characterised spectroscopically and also by X-ray crystallography. Cytotoxicity of these complexes was studied in vitro in three human cancer cell lines (CH1, A549 and SW480) using the MTT assay.