Chloride and ethyl ester morpholine thiourea derivatives and their Ni(II) complexes. Crystal and molecular structures of the thiourea derivative L-leucine methyl ester and its complexes with Cu(II) and Pt(II). Growth of the pathogenic fungus Botrytis

摘要

We have synthesized a series of ligands (1,3,4,6 and 7) and some of their complexes with Ni(II), Cu(II) (2,5,8 and 9). These compounds were studied and characterized by elemental analysis, IR and UV-Vis spectra, conductivity measurements in solution, FAB~+/MS, ~1H and ~(13)C NMR, ESR, etc. Compound 7 crystallized in the orthorhombic space group P2_12_12_1, with Z=4, Unit cell parameters were as follows: a=21.307(2) A, #alpha#=90 deg, b=12.498(1) A, #beta#=90 deg, c=7.7232(4) A, #gamma#=90 deg. For seven of these compounds, the antifungal activity of a major pathogen responsible for important crop damage was studied. In general, inhibition by the ligands was higher than that of the complexes. When the thiourea was linked to some diethyl groups, the compounds showed higher antifungal activity than the morpholine groups. Compound 3 achieved total inhibition (100%).