Preparation and cell growth inhibitory activity of [PtR2L2] (R=polyfluorophenyl, L-2=diene, cyclohexane-1,2-diamine (chxn) or cis-(dimethyl sulfoxide)(2)) and the X-ray crystal structure of [Pt(C6F5)(2)(cis-chxn)]

摘要

A range of [PtR2(chxn)] (R=C6F5, o-HC6F4, p-HC6F4, p-MeOC6F4, or 3,5-H2C6F3; chxn=cyclohexane-1,2-diamine) and cis[PtR2(dmso)(2)](R=C6F5, p-HC6F4 or p-MeOC6F4; dmso=dimethyl sulfoxide) complexes have been prepared from the corresponding [PtR2(diene)] (diene=cis,cis-cycloocta-1,5-diene (cod), hexa-1,5-diene (hex), norbornadiene (nbd) or dicyclopentadiene (dcy)) derivatives and have been spectroscopically characterized. A representative crystal structure of [Pt(C6F5)(2)(cis-chxn)] was determined and shows a slightly distorted square planar geometry for platinum with chxn virtually perpendicular to the coordination plane. The biological activity against L1210 and Ll210/DDP cell lines of these compounds together with the behaviour of other organoplatinum complexes, [PtR2L2] (L-2 = ethane-1,2-diamine (en) or cis-(NH2)(2)) have been determined. Despite the use of relatively inert fluorocarbon anions as leaving groups, moderate-high cell growth inhibitory activity is observed. None of the fluorocarbon complexes displayed any cross resistance with cisplatin.