DRUG-PROTEIN INTERACTIONS - TWO-SITE BINDING OF HETEROCYCLIC LIGANDS TO A MONOMERIC HEMOGLOBIN

摘要

The reactivity response of the heme proteins to the heterotropic effecters, purine, caffeine, theophylline, and (C2H5N+, have been examined. The heterotropic effecters influence the heme ligation affinities. The heme axial ligation of pyridine and pyrazole;have not influenced the hemoglobin's affinity for caffeine and theophylline. The imidazole ligation indicates a mutual interaction between the heme active site and the noncoordinate binding site. [References: 34]