COBALT(II), NICKEL(II), AND COPPER(II) COMPLEXES OF SULFANILAMIDE DERIVATIVES - SYNTHESIS, SPECTROSCOPIC STUDIES, AND ANTIBACTERIAL ACTIVITY, CRYSTAL STRUCTURE OF [CO(SULFACETAMIDE)(2)(NCS)(2)]

摘要

The synthesis and characterization of new coordination compounds of Co(II), Ni(II), and Cu(II) with sulfacetamide (N-[4-(amino-fenil)sulfonil]acetamide) is reported. The complex [Co(sulfacetamide)(2)(NCS)(2)] crystallizes in the triclinic space group P-1. The cell dimensions are a = 7.80(2) Angstrom, b = 8.327(9) Angstrom, c = 9.568(3) Angstrom, alpha = 90.5(1)degrees, beta = 90.5(1)degrees, gamma = 97.8(2)degrees, V = 616(1) Angstrom(3), Z = 2, and D-x = 1.689 g/cm(3). The final conventional R-factor = 0.039 (R(w) = 0.039) for 3535 ''observed'' reflections and 173 variables. The Co(II) is surrounded in a regular octahedral arrangement by two N-thyocianato from the NCS, two N-amino and two O-acetamido atoms from the sulfacetamide. Each sulfacetamide, acting as a bidentate ligand, chelates two Co(II) ions as a bridge through the N-amino and the O-acetamido atoms. IR, Reflectance Diffuse, EPR, and magnetic properties of the obtained complexes are discussed. The complexes were screened for their activity against E. Coli and S. aureus, showing an appreciable antimicrobial activity compared with the ligands. [References: 27]