Transition metal complexes of diclofenac with potentially interesting anti-inflammatory activity

摘要

An overview is given of the results of metal ion-diclofenac interactions. Several complexes have been synthesized at the University of Ioannina. Binuclear complexes, [Cu(L)(2)(H2O)](2). 2H(2)O and [CuL2(S)](2) where S is H2O, EtOH, DMSO, (CH3)(2)CO and DMF, and mononuclear complexes, [MnL2(H2O)], [FeL2(H2O)(2)], [CoL2(H2O)(2)]. 0.5H(2)O [CoL2(H2O)], [NiL2(H2O)(2)]. 2H(2)O [NiL2] and [PdL2]. 2H(2)O, have been characterized by spectroscopy, X-ray crystallography and electrochemical studies. The catalytic activity of these complexes was correlated to the reduction potential. Some of the complexes of diclofenac exhibit very promising anti-inflammatory activity and act as antioxidant compounds, a property that is absent from diclofenac. (C) 2000 Elsevier Science Inc. All rights reserved. [References: 37]