Interaction between NiCl2 and nucleobases, nucleosides and nucleotides

摘要

The interaction between NiCl2 and nucleobases, nucleosides and nucleotides has been studied by UV-Vis difference spectrophotometry, graphite furnace atomic absorption spectrophotometry, IR spectroscopy and high pressure liquid chromatography using the technique of continuous variation. The proposed structures of the complexes Formed were optimised and their electronic and vibrational spectra generated using the molecular modelling program HyperChem 5. Ni2+ reacts with guanine, 2'-dGMP, CMP, adenine and AMP to form 1:1 complexes Ni(Guanine)(H2O)(5), Ni(2'-dGMP)(H2O)(5) Ni(GMP)(H2O)(5), Ni(Adenine) (H2O)(5) and Ni(AMP)(H2O)(5) respectively. Tn these complexes, Ni2+ is believed to be bonded to the N7 atom of adenine and guanine. (C) 2000 Elsevier Science Inc. All rights reserved. [References: 32]