Consumption of Dried-bonito Broth Acutely Increases Peripheral Blood Flow in Humans

摘要

We investigated the acute effect of a single dose of dried-bonito broth (DBB) on peripheral blood flow using a laser Doppler blood flow meter. In a randomized, double-blind, crossover, placebo-controlled study, 19 healthy female subjects ingested DBB (4900 mg) or placebo. The peripheral blood flow was measured before ingestion and at 5, 10, 15, 20, 25, 30, 45, and 60 min after ingestion of the test diet. Blood flow significantly increased after DBB ingestion, and the area under the blood flow-time curves calculated up to 60 min (AUC_(0-60)) for the ingestion with DBB was significantly higher than that for the placebo ingestion (p < 0.001). Following consumption of lower dose of DBB (2450 mg), an increase in peripheral blood flow was observed and that the AUC_(0-60) after subjects consumed DBB was significantly higher than that after they consumed the placebo (p < 0.01). The mean AUC_(0-60) for the treatment with 4900 mg DBB was about 2 times that for 2450 mg DBB, suggesting that an orally administered single dose of DBB might have an acute dose-dependent effect on peripheral blood flow.