Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives.

Bi Y; Xu J; Wu X; Ye W; Yuan S; Zhang L

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Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives.

机译：17-羧酸修饰的23-羟基桦木酸酯衍生物的合成及细胞毒活性。

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New 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives were prepared and tested for cytotoxic activity on five cancer cell lines in vitro: all tested compounds showed stronger cytotoxic activity than 23-hydroxy betulinic acid and betulinic acid. In addition, compound 5a was tested for anti-tumor activity in vivo: it had much better anti-tumor activity than 23-OH betulinic acid and had similar anti-tumor activity with cyclophosphamide and 5-fluorouracil.

机译：制备了新的17-羧酸修饰的23-羟基桦木酸酯衍生物，并在体外对五种癌细胞系进行了细胞毒活性测试：所有测试化合物均显示出比23-羟基桦木酸和桦木酸更强的细胞毒活性。此外，还测试了化合物5a的体内抗肿瘤活性：它具有比23-OH桦木酸更好的抗肿瘤活性，并且与环磷酰胺和5-氟尿嘧啶具有相似的抗肿瘤活性。

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《Bioorganic and Medicinal Chemistry Letters》 |2007年第5期|共4页
作者
Bi Y; Xu J; Wu X; Ye W; Yuan S; Zhang L;
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原文格式 PDF
正文语种 eng
中图分类药学;生物化学;
关键词
betulinic acid; derivatives; Neoplasms; Esters; Carboxylic Acids; 肿瘤; 酯类; 羧酸类;

机译：betulinic acid;derivatives;Neoplasms;Esters;Carboxylic Acids;肿瘤;酯类;羧酸类;

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1. Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives. [J] . Bi Y, Xu J, Wu X, Bioorganic and Medicinal Chemistry Letters . 2007,第5期

机译：17-羧酸修饰的23-羟基桦木酸酯衍生物的合成及细胞毒活性。
2. Synthesis and Antitumor Activity of 17-carboxylic acid M odified A mide D erivatives of 3-hydroxy betulinic acid [J] . Yi Bi, Jin -Y i Xu, Fei Sun, Records of Natural Products . 2013,第4期

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3. Synthesis and cytotoxic activity of new betulin and betulinic acid esters with conjugated linoleic acid (CLA) [J] . Tubek B., Mitu?a P., Niezgoda N., Natural product communications . 2013,第4期

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Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives.

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