Equilibrium studies on reactive extraction of naproxen enantiomers using hydrophilic β-cyclodetrin derivatives extractants

摘要

A simple and low-cost method using liquid-liquid extraction coupled with complexation reactive technique has been developed for enantioselective separation of naproxen enantiomers. Three kinds of modified β-cyclo-dextrins including methyl-β-cyclodextrin (Me-β-CD), hydroxyethyl-β-cyclodextrin (HE-β-CD) and hydroxypro-pyl-β-cyclodextrin (HP-β-CD), were selected as hydrophilic chiral selectors for extraction naproxen from organic phase to aqueous phase. A systematic study of the factors affecting chiral separation performance were investigated. The experiment results obtained show that, HP-β-CD, HE-β-CD and Me-β-CD has stronger recognition abilities for S-naproxen than those for R-naproxen. Among the β-CD derivatives studied, HP-β-CD has the strongest ability for chiral recognition and separation. Excellent enantioselec-tivity (a) of 1.59 is obtained under the optimal conditions of pH of 2.5 and temperature of 5 °C.