The synthesis and molecular recognition study of β-cyclodextrin derivatives modified by spiro[2H-benzopyran-2,2'-indoline]

摘要

In this study, we adopted the condensation reaction between the aldehyde group in spiro[2H-benzopyran-2,2'-indoline] and the ethylene diamine in β-cyclodextrins to synthesize 1,3,3-trimethyl-6'-mono-(6-deoxy-ethylenedii-mine-β-cyclodextrin)-spiro[2H-benzopyran-2,2'-indoline] (β-CD-SPBI). The structure of the target compound was characterized by elemental analysis, NMR and IR spectroscopy. The UV-Vis and fluorescence spectroscopy were investigated in different solvents. The preliminary study of its molecular recognition was also conducted. The results indicated that β-CD-SPBI existed as two structural isomers, both of which showed significant fluorescent characteristics and β-CD-SPBI could showed the capacity of dual molecular recognition of a drug, ribavirin.