Synthesis and Alkaline Metal Ion Binding Ability of New Steroid Dimers Derived from Cholic and Lithocholic Acids

摘要

The synthesis and NMR spectra of steroid dimers being derivatives of cholic and lithocholic acid methyl esters,in which the steroid residues are linked by the terephthaloyl spacer,are described.The complexing ability of the dimers towards alkaline metal cations has been studied by the electrospray mass spectrometry.Cholic acid derivatives show affinity toward metal cations and anions.Binding of metal cations by methyl lithocholate dimer has not been detected.