Cyclodextrin-based Nanosponges for Drug Delivery

摘要

Nanosponges were prepared from beta-cyclodextrins as nanoporous materials for possible use as carriers for drug delivery.The structure of beta-cyclodextrin-based nanosponges was principally investigated by FT-IR,DSC and RX analyses.Sizes,morphology and toxicity were also examined.The capacity of the nanosponges to incorporate molecules within their structure was evaluated using drugs with different structures and solubilities.The nanosponges were found capable of carrying both lipophilic and hydrophilic drugs and of improving the solubility of poorly water-soluble molecules.