Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs genetic polymorphisms and plasma levels in hypertensive disorders of pregnancy

摘要

Karthikeyan et a/.1 published an interesting review in this journal on the relevance of matrix metaHoproteinases (MMPs) and their tissue inhibitors (TIMPs) for hypertensive disorders of pregnancy (HDP) and its complications. They have concluded that failure of regulation of the MMP/TIMP system in controlling the extracellular matrix remodeling may lead to diverse pathology, such as gestational hypertension (GH) and preeclampsia (PE). We would like to contribute additional, supportive data regarding plasma and genetic alterations in the MMP/TIMP system in HDP2"4 (Table 1).