In vitro antimicrobial synergy studies of carbapenem-resistant Acinetobacter baumannii isolated from intensive care units of a tertiary care hospital in Egypt

摘要

The increasing prevalence of multidrug-resistant and pan drug-resistant Acinetobacter baumannii as a cause of nosoconnial infections has led to the need for the reassessment of novel combinations of antibiotics as our only current viable option for handling such infections until a new therapeutic option becomes available. Two of the most commonly used methods for testing antimicrobial synergy are the Time-kill assay method and the E-test method, and these were the methods used in this study. Antibiotic combinations tested in this study were azithromycin and polymyxin, tobrannycin and polymyxin, polynnyxin and rifampicin, and tobramycin and rifampicin.