Advanced maternal age at childbirth and the development of uniparental disomy. A commentary on the proportion of uniparental disomy is increased in Prader-Willi syndrome due to an advanced maternal childbearing age in Korea

摘要

Advanced maternal age at childbirth (usually ^ 35 years old) is known to be a risk factor for the occurrence of non-disjunction at meiosis I.1 As non-disjunction at maternal meiosis 1 results in the generation of disomic oocytes and nuUisomic oocytes, fertilization of such abnormal oocytes and normal sperms leads to the production of trisomic and monosomic 2ygotes. Although such aneuploidies are usually incompatible with life, several types of aneuploidies such as trisomy 21 could permit the production of livebirths. Consistent with this, the frequency of newborns with trisomy 21 obviously increases with advanced maternal childbearing age.2