Anti-inflammatory and Anti-proliferative Properties of Chromolaena odorata Leaf Extracts in Normal and Skin-Cancer Cell Lines

摘要

Leaf extracts of Chromolaena odorata were evaluated for anti-inflammatory and anti-proliferative activities in normal and cancerous skin cell lines. Ethyl acetate extract was high in phenolic, flavonoid contents and exhibited antioxidant and free radical scavenging capacity. A dose-dependent decrease in LPS-induced TNF-a and IL~(-1)$ was observed in HaCaT cells treated with ethyl acetate extract. Hexane and ethyl acetate extracts showed cytotoxicity and arrest ofA431 cells in sub-Gl phase.