Volatile Constituents and Cytotoxic Activity of Khaya grandifoliola and Khaya senegalensis Flower Extracts

摘要

The volatiles obtained from fresh flowers of Khaya grandifoliola CDC and Khaya senegalensis AJuss. by hydro-distillation method were analyzed by gas chromatography and gas chroma-tography-mass spectrometry. Sesquiterpenes represent 86.32% and 80.86% of the identified volatile compounds of K. grandifoliola (KgO) and K. senegalensis (KsO) oil, respectively. Caryophyllene-oxide (23.01%), isocaryophyllene (Z) (21.99%), and a-humulene (13.46%) were the main compounds identified in KgO, whereas in KsO theywere caryophyllene oxide (14.85%), $-caryophyllene (43.59%), and a-humulene (15.72%). The volatiles were tested for cytotoxic activity against liver (HepG-2), breast (MCF-7), and colon (HCT-116) human cancer cell lines. K. grandifoliola and K. senegalensis o;7s displayed cytotoxic activity with IC50 (21.6, 26.1, and 37.6 xg.mL) and (61.1, 79.7, and 61 ig. ml), respectively. Sesquiterpene content of Khaya oils may contribute to their cytotoxic activity.