2013 American College of Clinical Pharmacology Annual Meeting September 22nd – 24th Bethesda, Maryland

摘要

Statement of Purpose, Innovation or Hypothesis: Relapse to drug misuse may follow exposure to drug cues, presumably because the cues activate Pavlovian associations that may be subject to reconsolidation each time they are recalled. Disruption of reconsolidation by propranolol in a memory-reactivation session may provide enduring protection against cue-induced craving and relapse. We evaluated the effects of propranolol, a beta-blocker, on reconsolidation of cue-induced drug cravings in methadone-maintained cocaine users.