Clean and Efficient Synthesis of Pyrazole Derivatives in Aqueous Media

摘要

A series of 5-aryl-1H-pyrazole derivatives were synthesized via the reaction of 3-(dimethylamino)-1-arylprop-2-en-1-one with hydrazine in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction condition, high yields, and an environmentally benign procedure.