Polycyclic N-Heterocyclic Compounds. Part 78: Synthesis of N-[2-([1,2,4] Oxadiazol-5-yl)cyclohepten-1-yl]formamide Oximes and Their Evaluation as Inhibitors of Platelet Aggregation

摘要

N-[2-([1,2,4]Oxadiazol-5-yl)cyclohepten-1-yl]formamide oximes were synthesized by fusion of (6,7,8, 9-tetrahydro-5H-cyclohepta[1,2-d]pyrimidin-4-yl)amidines with hydroxylamine hydrochloride through a subsequent rearrangement reaction. Effects of the products as well as the structurally related N-[4-([1,2,4]oxadiazol-5-yl)-2, 3-dihydro[1]benzoxepin-5-yl]formamide oximes and N-[4-([1,2,4]oxadiazol-5-yl)-2,3-dihydro[1]benzothiepin-5-yl] formamide oximes on platelet aggregation were evaluated.