Silica-supported synthesis of some 1,3,5-trisubstituted 2-pyrazolines under solvent-free and microwave irradiation conditions

摘要

A simple method for the synthesis of 2-pyrazolines is described which occurs on silica surface under solvent-free conditions within 110-180 sec using microwave irradiation. The results obtained indicate that the use of silica gel as a support in pyrazoline formation reactions can have a profound effect on reaction rates and yields and cause cleaner reaction conditions.