Chemistry of an Unexplored Heterocyclic Ring System: Versatile Synthesis of 5-Aryl-2,3,4-benzothiadiazepine 2,2-dioxides

摘要

The article gives insight into the synthetic approach of a practically new heterocyclic ring system, 2,3,4-benzothiadiazepines. Starting from the easily available phthalides, an efficient synthesis of 5-aryl-2,3,4-benzothiadiazepine 2,2-dioxides is described here. Owing to their close structural similarity to 2,3-benzodiazepines and 2,3-benzodiazepine-4-ones, two well-known bioactive compound families, the new derivatives can be of importance in medicinal chemistry.