Synthesis and Biological Activity Studies of Some Novel Mannich Bases of Benzotriazolyl Triazoles

摘要

A series of substituted phenyl methyl piperazine triazolyl benzotriazoles 4a, 4b, 4c, 4d, 4e, 4f, 4g have been synthesized through the Mannich reaction of substituted phenyl triazolyl benzotriazoles 3a, 3b, 3c, 3d, 3e, 3f, 3g. The substituted phenyl triazolyl benzotriazoles were prepared from benzotriazolyl acetohydrazide, where the cyclization was facilitated through ammonium acetate and aryl aldehydes. The IR, H-1 NMR, mass spectral data and elemental analysis were performed to assign the structure. All the newly synthesized compounds were screened for their antimicrobial and antioxidant activity.