Synthesis of Novel 2-Aryloxy-3-(4-chlorophenyl)-8-substituted-5-aryl-8,9-dihydro-3H-chromeno[2,3-d]pyrimidine-4,6(5H,7H)-dione Derivatives

摘要

Twenty-one novel 2-aryloxy-3-(4-chlorophenyl)-8-substituted-5-aryl-8,9-dihydro-3H-chromeno[2,3-d]pyrimidine-4,6(5H,7H)-diones 5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j, 5k, 5l, 5m, 5n, 5o, 5p, 5q, 5r, 5s, 5t, 5u were designed and easily synthesized via a tandem aza-Wittig reaction. Treatment of iminophosphorane 3 with 4-chlorophenyl iso-cyanate gave carbodiimide 4, which reacted with phenols to provide the title compounds in 50-73% isolated yields. All compounds 3 and 5 were confirmed by infrared, H-1-NMR, mass spectra, and elemental analysis, and compound 5a was further analyzed by single-crystal X-ray diffraction, and the title compounds were synthesized with the purpose of bringing in some new chemical and biological interests.