A New Iodonium Ylide-Based Three-Component Reaction Leading to 2-Spirosubstituted Dihydrofurans under Microwave Irradiation

摘要

A new iodonium ylide-based three-component reaction for the synthesis of highly functionalized 2-spirosubstituted dihydrofurans starting from readily available common reactants has been developed under microwave irradiation. The procedure is facile, avoiding time-consuming and costly syntheses, tedious work-up and purifications of precursors as well as protection/deprotection of functional groups. This method is very efficient because of short reaction times and easy work-up and provides an efficient strategy for the construction of the polysubstituted spiro dihydrofuran skeleton.