Novel 3-(2-Oxo-2H-benzo[b][1,4]oxazin-3-yl)propanoates from dimethyl-2-oxoglutarate and test of their biological activity

摘要

Five novel 3-(2-oxo-2H-benzo[b][1,4]oxazin-3-yl)propanoates were synthesized under mild conditions from 2-aminophenols and dimethyl-2- oxoglutarate. Biological assays of these 1,4-benzoxazinones were conducted with three bacterial strains and one yeast. All compounds were active against a Candida albicans ATCC 10231, whereas only methyl 3-(6-methyl-2-oxo-2H-benzo[b] [1,4]oxazin-3-yl)propanoate showed a general moderate activity against the bacterial strains tested.