Synthesis of Novel 2-Oxoquinoline Derivatives via Ugi-Four-Component-Heck Reaction

摘要

The present study provides an efficient strategy for the preparation of novel N-substituted-4-methyl-quinolin-1(2H)-one derivatives via two-step Ugi/Heck reaction. The procedure is based on the Ugi coupling between 2-bromoanilines, various aromatic aldehydes, vinylacetic acid, and isocyanides, and then intramolecular Heck reaction, which leads to the formation of the title compounds in good yields.