Polyethylene Glycol Mediated, One-Pot, Three-Component Synthetic Protocol for Novel 3-[3-Substituted-5-mercapto-1,2,4-triazol-4-yl]- spiro-(indan-10,2-thiazolidin)-4-ones as New Class of Potential Antimicrobial and Antitubercular Agents

摘要

Antibiotics are among the most prescribed drugs in the world today. Several bacterial infections such as diarrhea, food poisoning, and rheumatic, salmonellosis extraintestinal, and intestinal wall infections are caused by multidrug resistant Gram-positive and Gram-negative pathogens [1,2]. This resistance of pathogenic bacteria toward available antibiotics is rapidly becoming a major threat worldwide to human health. In addition, the primary and opportunistic fungal infections continue to increase dramatically because of the growing number of immunocompromised hosts such as AIDS patients or those undergoing anticancer chemotherapy or transplantations [3-5]. Not only this, they also easily gained resistance, which is the main problem encountered in developing safe and efficient antifungal agents. Therefore, design of new antimicrobial compounds in structural classes to deal with these problems is of prime interest.