Synthesis and anticancer activity of new substituted pyrazoles and their derived 1,2,4-triazoles and sugar derivatives

摘要

New substituted pyrazole, thiazole, and 1,2,4-triazole derivatives were synthesized. The sugar hydrazones, their acetylated derivatives as well as their derived acyclic C-nucleoside analogs, and the thioglycosides of the 1,2,4-traizole derivatives were also prepared. The antitumor activity of some of the synthesized compounds were studied, and a number of the tested compounds showed significant activities.