An efficient and clean Michael addition of indoles to electron-deficient olefins under solvent- and catalyst-free condition

摘要

An efficient Michael addition of indoles to electron-deficient olefins under solvent- and catalyst-free condition afforded biologically important 3-substituted indole derivatives in good to excellent yields was reported. The acidic N-H proton of indole plays a key role in Michael addition of indoles to electron-deficient olefins. This very simple procedure provides an efficient and clean process for the synthesis of indole derivatives.