Microwave-mediated synthesis and antibacterial activity of some novel 2-(substituted biphenyl) benzimidazoles via Suzuki-Miyaura cross coupling reaction and their N-substituted derivatives

摘要

A series of some novel 2-(substituted biphenyl) benzimidazoles and their N-substituted derivatives were synthesized via microwave-mediated Suzuki-Miyaura coupling of 2-(4-iodophenyl)-1H-benzimidazole or 2-(4-iodophenyl)-6-amino-1H- benzimidazole and arylboronic acids. The method reported herein offers advantageous shorter reaction times, higher yields and is applicable to a large set of substrates. All the synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus and Salmonella typhimurium bacterial species.