Synthesis and characterization of N-arylsulfonylazetidines

摘要

A convenient method for the synthesis of N-arylsulfonyl azetidines using N-(3-bromopropyl)arylsulfonamide with cesium carbonate and potassium iodide in DMF is reported. The reaction conditions are optimized and seven N-arylsulfonyl azetidines have been synthesized in good yield using this method. The structures of compounds 2a and 2e were determined by X-ray crystallography.