1,3-Dipolar cycloaddition reaction: Synthesis and configuration of norcantharidin derivatives of substituted aromatic amine

摘要

A series of eighteen novel compounds that have potential pharmacological properties has been synthesized by 1,3-dipolar cycloaddition reactions of 5,6-dehydronorcantharidin derivatives of substituted aromatic amine with nitrile oxide. The synthesis was carried out following straightforward three-step procedure described herein. IR, H-1 nmr and ins, H-H cosy and Noesy Cyclonoe, confirmed the structure of all products respectively. The biological evaluation of three series of norcantharidin analogues against HL60 cell has been screened.