Synthesis and antimicrobial activity of novel spirocompounds with pyrazolone and pyrazolthione moiety

摘要

The paper focuses on the utility of 2-pyrazoline-5-ones and 2-pyrazoline-5-thiones as active Michael donors for the synthesis of novel spirocyclohexanone derivatives. The sulphur containing compounds when screened for antimicrobial activity showed promising inhibition of S. Typhi, S Aures and E Coli bacteria.