Synthesis of alpha-diaminomethylenebutyrolactams by the reaction of alpha-cyanobutyrolactams with N-trimethylsilylamines

摘要

Successive treatment of alpha-cyanobutyrolactams 1 with N-trimethylsilylamines and water gave the corresponding alpha-dianlinomethylenebutyrolacatms 2 in good yields. In the NOESY spectra of 2, the E isomer, the NOE observed between beta-CH2 (butyrolactam) and N-CH2 (morpholine, pyrrolidine) or N-CH3 (dimethylamine) indicated a cis configuration of these groups.