SYNTHESIS OF CYCLIC AND ACYCLIC NUCLEOSIDE ANALOGUES HAVING A THIOPHENE OR DIHYDROTHIOPHENE RING FUSED TO THE D SIDE OF AN URACIL

摘要

Synthesis of cyclic and acyclic nucleosides was achieved by alkylation of various new aglycones following the Vorbruggen and Niedballa's procedure [6]. The analytical results allowed us to conclude that the alkylation occured on N1 site and led to the beta anomeric form for the cyclic nucleosides. [References: 23]