Synthesis of bis-intercalators with an aminochloropyrimidine ring as potential anticancer agents

摘要

The synthesis of a series of polymethylene chain-bridged aminochloropyrimidines as potential DNA intercalators is described. N,N'-Bis(2-amino-6-chloro-4-pyrimidyl)-1,3-diaminopropane (3), N,N'-bis(2-amino-6-chloro-4-pyrimidyl)-1,4-diaminobutane (4), N,N'-bis(2-amino-6-chloro-4-pyrimidyl)-1,6-diaminohexane (5), N,N'-bis(2-amino-6-chloro-4-pyrimidyl)-1,8-diaminooctane (6), N,N'-bis(2-amino-6-chloro-4-pyrimidyl)-1,10-diaminodecane (7), and N,N'-bis(2-amino-6-chloro-4-pyrimidyl)-1,12-diaminododecane (8) were synthesized from 2-amino-4,6-dichloropyrimidine (1) and 1,3-diaminopropane, 1,4-diaminobutane, 1,6-diaminohexane, 1,8-diaminooctane, 1,10-diaminodecane, and 1,12-diaminododecane, respectively. The spectral data and other physical properties of the new compounds are discussed.