Studies with azoles and benzoazoles: A novel simple approach for synthesis of 3-functionally substituted 3-acylindoles

摘要

3-Substituted acylindoles 8 are obtained via refluxing carboxylic acids with indole in acetic anhydride solutions. The formed 3-substituted acylindole 8a is readily converted into 4-aminopyrazol-3-ylindoles 20, and into 22. Indole reacts with chloroacetyl chloride to yield: 3-chloroacetylindole 9 which could also be utilized for synthesis of a number of 3-substituted indoles.