Preparation of Novel 2-(Benzo[b]furan-2-yl)-1H-imidazolines for Photoafinity Labelling and Affinity Isolation of Imidazoline Binding Proteins

摘要

The preparations of 5-aminoefaroxan 8 and 5-azidoefaroxan 9, which retain the capacity to stimulate insulin secretion via the putative I_3 imidazoline receptor and are useful biological tools for affinity chromatography studies and photoaffinity labelling studies of imidazoline bidnign proteins, are described.